One Colorado is a state-level LGBTQ advocacy organization. 
One Colorado has two suborganizations, the One Colorado Education Fund, and the One Colorado PAC. One Colorado Education Fund is a non-profit organization that provides information on LGBTQ related issues and works to public support.  One Colorado PAC is a political action committee that provides resources to political candidates.
One Colorado focuses on LGBT health, schools, maintaining pro-LGBT policies, transgender advocacy, and LGBT immigrants.  One Colorado has two suborganizations, the One Colorado Education Fund, and the One Colorado PAC. One Colorado Education Fund is a non-profit organization that provides information on LGBTQ related issues and works to public support.  One Colorado PAC is a political action committee that provides resources to political candidates. In 2016, the One Colorado PAC endorsed 50 candidates in the House of Representatives and the Senate. 
In 2020, One Colorado rallied for the four-month Colorado legislative session to support bills related to LBGT issues. One of these bills was House Bill 1061, the HIV Infection Prevention Medications Bill that allows people to access HIV prevention medications without a prescription. The organization also supports adding gender identity and expression to the Colorado Anti-Discrimination Act, ending the use of the so-called “gay panic” legal defense, and training families to care for LGBT children.  One Colorado also offers trainings workshops, consulting, and speaking engagements covering various of topics related to LGBTQ issues.  One Colorado also writes publications such as reports about various LGBT related issues. 
One Colorado is a member of the Equality Federation,  an advocacy organization that is focused on LGBT issues.  One Colorado, through the One Colorado Education Fund, also started the Colorado Gender and Sexuality Alliance Network, a coalition of secondary-school clubs with the goal of combating bullying and harassment against LGBT students in their schools.  The Colorado GSA Network also provides resources to students, educators, and the public about this issue. 
Nadine Bridges is the executive director of One Colorado.  She previously worked as the director an LGBT youth organization called Rainbow Alley. She also volunteered with the Peace Corps in Nicaragua and managed the Community Health Division for Boulder County Public Health. She currently teaches at the University of Denver’s Graduate School of Social Work and is a board member of the Alexander Foundation. Bridges graduated from the College of Charleston with a bachelor’s degree in biology and from the University of Denver with a master’s degree in social work.