The JPB Foundation is a private foundation created by Barbara Picower in 2011. It is one of the largest grant-making foundations in the United States.  Focused on medical, environmental, and poverty issues, the Foundation makes grants to a number of left-of-center advocacy and community organizing groups. 
Picower opened the Foundation after the closure of her prior grant-making group, the Picower Foundation, and two years after the death of her husband, Jeffry Picower. The Picowers were the recipients of billions of dollars in investments through Bernie Madoff’s Ponzi scheme, $7.2 billion of which was lost in a civil lawsuit.
The Foundation’s initial funding came from Barbara and Jeffry Picower’s assets. Its $1.1 billion in initial assets was nearly doubled by the end of 2012 thanks to Jeffry Picower’s assets. 
Most of the Foundation’s revenues came from sales of assets in 2017. $17 million came from donations and grants in 2017, over $42 million from investments, and over $196 million from sales of assets. 
Its assets as of 2017 totaled over $4 billion, with over $264 million in revenues.
The Foundation focuses on three areas of interest: poverty, medical research, and the environment. Each area has several sub-focuses that match its values.  The Foundation’s two Advisory Committees – one focused on poverty and the environment, the other focused on medical issues – oversee grant-making decisions. 
The Foundation funded dozens of organizations in 2017. Among the JPB Foundation’s grant recipients are numerous left-of-center advocacy and public policy organizations. 
JPB Foundation supports a number of left-of-center multi-issue advocacy groups. The Democratic Party establishment-aligned think tank Center for American Progress received $3.4 million for anti-poverty efforts in 2017; the group was also promised $5.9 million in future grants. The liberal political advocacy group Color of Change received $500,000 in 2017 and a future grant promise of $500,000; Advancement Project received $750,000. 
JPB Foundation provided the social-liberal litigation and advocacy group American Civil Liberties Union and its affiliated organizations with $1.175 million. The Tides Center received $800,000 in 2017 and a promise of $100,000 for future funding. 
High-dollar donations are common for the Foundation. It gave Center for Community Change $4.45 million in 2016, nearly a third of that organization’s revenues in 2016.  It gave the non-profit advisory organization The Bridgespan Group over $4 million in 2016.  Barbara Picower is on The Bridgespan Group’s Board of Directors. 
JPB Foundation is a major funder of the Planned Parenthood Federation of America; in 2017, it provided the group with $6.9 million through three grants. Planned Parenthood’s South Florida affiliate received $400,000.
In 2017, JPB Foundation provided the former Planned Parenthood research arm, and current abortion and abortion-related research group, Guttmacher Institute with $875,000. Likewise, the abortion legal group Center for Reproductive Rights received $1.45 million. 
The commentary and news magazine American Prospect received $200,000, with $400,000 more funding scheduled in future years. Grist Magazine, an environmentalist web magazine, also received funding from the Foundation in 2017. 
A number of environmental groups received funding. Earth Day Network’s $50,000 was dwarfed by other groups’ grants, such as the $2 million provided to Earthjustice and $1,042,700 provided to the Sierra Club. 
The Picowers fought against a lawsuit from 2008 – when the Bernie Madoff investment scams were exposed – until the U.S. Attorney General’s office intervened in ongoing lawsuits against the Picowers’ estate in 2011. That lawsuit ended in $7.2 billion of Jeffry Picower’s assets being provided to Madoff’s victims. 
Picower, McNamara, Chief Operating Officer April Freilich, and others who are in senior staff and board positions for the JPB Foundation were sued in connection with Jeffry Picower’s alleged involvement in Madoff’s schemes. While the Picowers claimed they were simply beneficiaries, Madoff alleged that they were involved in the scams. The lawsuit was dismissed multiple times.